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From CBS, April 4, 2024: "These are some of the horrors of temporomandibular joint disorders, known as TMJ or TMD, which afflict up to 33 million Americans, according to the National Institutes of Health. Dentists have attempted to heal TMJ patients for close to a century, and yet the disorders remain misunderstood, under-researched, and ineffectively treated, according to an investigation by KFF Health News and CBS News." Dr. Kyriacos Athanasiou, Distinguished Professor of Biomedical Engineering at UCI and Cartilage Inc.'s Founder and Scientific Advisor, was interviewed for this news feature.
September 21, 2023: Cartilage Inc. received a $252,000 Phase I Small Business Technology Transfer (STTR) grant from the National Institutes of Health (NIH). This grant will investigate their injectable cartilage implant, Chondrofluid®, for arthroscopic repair of knee cartilage. This is Cartilage Inc.'s third federal award. Dr. Dean Wang, UCI's Chief of Sports Medicine Division and Cartilage Inc.'s Orthopaedic Surgery Consultant, serves as Principal Investigator for this grant.
July 11, 2023: A patent for Methods and Systems for Conserving Highly Expanded Cells, a foundational technology underlying Hyaleon® and Chondrofluid®, was issued by the United States Patent and Trademark Office (USPTO).
From OCBJ, May 22, 2023: Cartilage Inc., a biomedical startup from the University of California Irvine, is developing a product that will restore TMJ function by regenerating missing tissue and repairing defects in the jaw joint. (Page 16: Startups & Innovations)
From CIRM, April 27, 2023: The Board of the California Institute for Regenerative Medicine (CIRM) approved investing nearly $89 million in projects from its Clinical and Translation programs at its April meeting. Nearly $39 million will support four projects in the agency’s Clinical program, which speeds up support and provides funding for eligible stem cell and gene therapy-based projects through any stage of clinical trial activity. Included in the awards is a $6,000,000 grant to Kyriacos Athanasiou to perform IND-enabling studied for Hyaleon® for treatment of the TMJ disc complex.
From UCI Beall Applied Innovation News, March 31, 2021: "UC Irvine (UCI) startup Cartilage Inc., a Wayfinder team, recently received a $256,000 National Science Foundation (NSF) phase one Small Business Innovation Researcher (SBIR) grant. The funds will be used to develop their latest product, a special injectable cartilage glue designed to fix Cartilage’s and other commercially available implants and to help with the integration and healing of cartilage implants into surrounding tissues. This is the second SBIR grant the team has received in less than six months." Dr. Wendy Brown, Cartilage Inc.'s Director of Regulatory and Clinical Affairs, serves as Principal Investigator for this grant.
From UCI Beall Applied Innovation News, October 20, 2020: "UC Irvine startup Cartilage Inc., a Wayfinder team, recently received a Phase I $252,000 Small Business Innovation Research (SBIR) grant from the National Institutes of Health (NIH). The startup will use this grant to investigate the feasibility of their product Hyaleon®, a scaffold-free, tissue-engineered cartilage implant, capable of healing both large and small cartilage defects." Dr. Wendy Brown, Cartilage Inc.'s Director of Regulatory and Clinical Affairs, serves as Principal Investigator for this grant.
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